Publications

Dinglasan Publications

Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen.
Dinglasan R.R., Kalume, D.E., Kanzok, S.M., Ghosh, A.K., Muratova, O., Pandey, A., Jacobs-Lorena, M. Proc Natl Acad Sci USA 2007, 104 (33): 13461-13466. PMID: 17613553.

Expression, immunogenicity, histopathology, and potency of a mosquito- based malaria transmission-blocking recombinant vaccine.
Mathias, D.K., Plieskatt, J.L., Armistead, J.S., Bethony, J.M., Abdul-Majid, K.B., McMillan, A., Angov, E., Aryee, M.J., Zhan, B., Gillespie, P., Keegan, B., Jariwala, A. R., Rezende, W., Bottazzi, M.E., Scorpio, D.G., Hotez, P.J., Dinglasan, R.R. Infection & Immunity. 2012, 80, 1606. PMID: 22311924.

Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of falciparum and vivax malaria.
Armistead JS, Morlais I, Mathias DK, Jardim JG, Joy J, Fridman A, Finnefrock AC, Bagchi A, Plebanski M, Scorpio DG, Churcher TS, Borg NA, Sattabongkot J, Dinglasan RR. Infection & Immunity, 2014 82(2):818-29. doi: 10.1128/IAI.01222-13. PMID: 24478095

Plasmodium falciparum Ookinetes Require Mosquito Midgut Chondroitin Sulfate Proteoglycans for Cell Invasion.
Dinglasan R.R., Alaganan, A., Ghosh, A. K., Saito, A., van Kuppevelt, T.H., Jacobs-Lorena, M. Proc Natl Acad Sci USA 2007, 104 (40): 15882-15887. PMID: 17873063.

A bioinformatics approach for integrated transcriptomic and proteomic comparative analyses of model and non-sequenced anopheline vectors of human malaria parasites.
Ubaida Mohien, C, Colquhoun, D.R., Mathias, D.K., Gibbons, J.G., Armistead, J.S., Rodriguez, M.C., Rodriguez, M.H., Edwards, N.J., Hartler, J, Thallinger, G.G., Graham, D.R., Martinez-Barnetche, J, Rokas, A, Dinglasan, R.R. Molecular & Cellular Proteomics, 2012 Oct 17. PMID: 23082028.

A Small Molecule Glycosaminoglycan Mimetic Blocks Plasmodium Invasion of the Mosquito Midgut.
Mathias DK, Pastrana-Mena R, Ranucci E, Tao D, Ferruti P, Ortega C, Staples GO, Zaia J, Takashima E, Tsuboi T, Borg NA, Verotta L, Dinglasan RR.PLoS Pathogens, 2013, 9 (11): e1003757. doi:10.1371/journal.ppat.1003757. PMID: 24278017.

Molecular Profiling of Phagocytic Immune Cells in Anopheles gambiae Reveals Integral Roles for Hemocytes in Mosquito Innate Immunity.
Smith RC, King JG, Tao D, Zeleznik OA, Brando C, Thallinger GG, Dinglasan RR.Mol Cell Proteomics 2016 Nov;15(11):3373-3387. doi: 10.1074/mcp.M116.060723. PMID: 27624304

Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology.
Tao D, Ubaida-Mohien C, Mathias DK, King JG, Pastrana-Mena R, Tripathi A, Goldowitz I, Graham DR, Moss E, Marti M, Dinglasan RR. Mol Cell Proteomics. 2014 Oct;13(10):2705-24. doi: 10.1074/mcp.M114.040956. PMID: 25056935

Structural analysis of the Anopheles gambiae midgut alanyl aminopeptidase N reveals a novel malaria transmission-blocking vaccine B-cell epitope.
Atkinson, SC, Armistead JS, Mathias DK, Sandeu MM, Tao D, Borhani-Dizaji N, Tarimo BB, Morlais I, Dinglasan RR*, Borg NA*. Nature Structural & Molecular Biology. 2015 22(7):532-9. doi: 10.1038/nsmb.3048. PMID: 26075520

The Selection of a Hepatocyte Cell Line Susceptible to Plasmodium falciparum Sporozoite Invasion That is Associated With Expression of Glypican-3.
Tweedell RE, Tao D, Hamerly T, Robinson TM, Larsen S, Grønning AGB, Norris AM, King JG, Law HCH, Baumbach J, Bergmann-Leitner ES, Dinglasan RR. Frontiers in Microbiology 2019. 10:127. doi: 10.3389/fmicb.2019.00127. eCollection 2019. PMID: 30891005  

A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir.
Tao D, Mcgill B, Hamerly T, Kobayashi T, Khare P, Dziedzic, Leski T, Holtz A, Shull B, Jedlicka AE, Walzer A, Slowey PD, Slowey CC, Nsango, SE, Stenger DA, Chaponda M, Mulenga M, Jacobsen KH, Sullivan DJ, Ryan SJ, Ansumana R, Moss, WJ, Morlais, I, and Dinglasan RR. Science Translational Medicine 2019 11 (473). pii:eaan4479. DOI: 10.1126/scitranslmed.aan4479 PMID: 30602535

Naturally acquired immunity against immature Plasmodium falciparum gametocytes.

Dantzler KW, Ma S, Ngotho P, Stone WJR, Tao D, Rijpma S, De Niz M, Nilsson Bark SK, Jore MM, Raaijmakers TK, Early AM, Ubaida-Mohien C, Lemgruber L, Campo JJ, Teng AA, Le TQ, Walker CL, Hermand P, Deterre P, Davies DH, Felgner P, Morlais I, Wirth DF, Neafsey DE, Dinglasan RR, Laufer M, Huttenhower C, Seydel K, Taylor T, Bousema T, Marti M. Science Translational Medicine, 11(495). pii: eaav3963. DOI: 10.1126/scitranslmed.aav3963 PMID: 31167926 PMCID: PMC6653583

Critical size limit of biodegradable nanoparticles for enhanced lymph node trafficking and paracortex penetration.
Howard G, Verma G, Ke, X. Thayer, WM, Hamerly T, Baxter VK, Lee JE, Dinglasan RR*, Mao HQ* Nano Res. 2019, 12(4): 837–844 https://doi.org/10.1007/s12274-019-2301-3 PMID: 33343832

Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes a
egypti
Mosquitoes.
Boyles SM, Mavian CN, Finol E, Ukhanova M, Stephenson CJ, Hamerlinck G, Kang S, Baumgartner C, Geesey M, Stinton I, Williams K, Mathias DK, Prosperi M, Mai V, Salemi M, Buckner EA, Lednicky JA, Rivers AR, Dinglasan RR.mSphere. 2020 Apr 29;5(2):e00316-20. doi: 10.1128/mSphere.00316-20. PMID: 32350095

Clustered Rapid Induction of Apoptosis Limits ZIKV and DENV-2 Proliferation in the Midguts of Aedes aegypti
Ayers JB, Coatsworth HG, Kang S, Dinglasan RR, Zhou L. Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti. 2021 Communications Biology  4(1):69. doi: 10.1038/s42003-020-01614-9. PMID: 33452408

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First in human clinical trials of the AnAPN1 malaria transmission-blocking vaccine

Former director of the PATH Malaria Vaccine Initiative, Christian Loucq, M.D., says it is exciting to see Dinglasan's concept moving toward a clinical trial. "There are very interesting issues to be addressed in this project which span the technical, immunological, strategic, regulatory and behavioral," says Dr. Loucq, who also formerly directed the International Vaccine Institute. "A transmission-blocking vaccine would be the most elegant solution to the problem of malaria."

Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti

Jasmine's 1st first-author paper (Yay Jasmine!) that dissects very early innate immune defense mechanisms of mosquito vectors following infection with flaviviruses.

UF Professor of Infectious Diseases, Dr. Rhoel Dinglasan, discusses the new saliva COVID tests